![]() Interactions between TP-conjugated repurposed drugs and the target sites of the SCoV-SG structure.Ĭonclusion: The study concluded that TP-conjugated repurposed drugs may be effective in preventing COVID-ġ9, and therefore, in vitro, in vivo, and clinical trial studies are required in detail. The results of molecular docking analysis showed higher efficiency and significantly enhanced and improved Results: TAT-peptides are well-characterized immune enhancers that are used in intracellular drug delivery. Further docking investigation was completed with PatchDock and was visualized by the discovery of the ![]() Methods: Molecular docking analysis was performed to study the interaction of repurposed drugs and drugsĬonjugated with the TAT-peptide with target SARS-CoV-2 spike glycoprotein (PDB ID: 6VYB) using Auto-ĭock. (LPV), favipiravir (FPV), remdesivir (RMV), hydroxychloroquine (HCQ), molnupiravir (MNV) and nirmatrelvir TAT-peptide 47-57(GRKKRRQRRRP)-conjugated remodified therapeutics such as ritonavir (RTV), lopinavir Objective: The major objectives of the current study are to conduct a molecular docking study investigation of The SARS-CoV-2 spike (SCoV-SG) is the foremost drug target among coronaviruses. Vaccines against COVID-19 is notably lower, there is an urgent need to develop a potential drug to treat thisĭeadly disease. Since the efficacy of available drugs and May lessen the effectiveness of the currently available vaccines. The COVID-19 vaccines currently undergoing clinical trials or already in use should provideĪt least some protection against SARS-CoV-2 however, the emergence of new variations as a result of mutations A total of 448,327,303 documented cases and 6,028,576 deaths have been reported as Englewood Cliffs, NJ, Educational Technology Publications.Background: In late 2019, a highly infectious and pathogenic coronavirus was recognized as SevereĪcute Respiratory Coronavirus 2 (SARS-CoV-2), which causes acute respiratory disease, threatening human Towne, D.M.: Learning and Instruction in Simulation Environments. Towle, B.: Authoring Tools for Learning How to Manage Complex Scenarios, Northwestern University. Schank, R.C.: Goal-Based Scenarios, Institute for the Learning Sciences, Tech Report 36. Hillsdale, NJ, Lawrence Erlbaum Associates. Murray, T.: “Authoring Intelligent Tutoring Systems: Analysis of the state of the art.” International Journal of AI and Education 10(1). ![]() International Conference on the Learning Sciences, Evanston, IL, Association for the Advancement of Computing in Education. M.Y.: Design Choices for Learning-by-Doing Software: When to Choose Advise. Stillwater, OK, Fire Protection Publications, Oklahoma State University. Interational Fire Services Training Association: Essentials of Firefighting, Third Edition. A.: An Authoring Tool for Procedural-Task Training, Northwestern University. Institute for the Learning Sciences, Tech Report 22. (1996)įerguson, W., Bareiss, R., Birnbaum, L., Osgood, R.: ASK Systems: An Approach to the Realization of Story-Based Teachers. (demo) International Conference on the Learning Sciences, Evanston, IL, Association for the Advancement of Computing in Education. (1998)ĭrake, L.: The Instructional Simulation Builder. Brown, J.S., Collins, A., Duguid, P.: “Situated Cognition and the Culture of Learning.” Educational Researcher 18 (1989) 32–42ĭobson, D.: Authoring tools for investigate-and-decide learning environments, Northwestern University.
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